Tag: tirzepatide peptide

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7 Benefits of Tirzepatide – What’s The Skinny?

Tirzepatide

What is Tirzepatide?

You may have heard of the prescription medications Zepbound or Mounjaro.  Both of these drugs have the same active ingredient – Tirzepatide, which is a synthetic peptide.  The difference between them lays in what conditions they are approved to treat.  For Zepbound, weight loss is the targeted objective, while Mounjaro is for treatment of Type 2 diabetes.   Tirzepatide is the first dual GLP-1 and glucagon-like peptide 1 (GIP) receptor agonist, and has shown in research studies to show significant beneficial effects like lowering blood sugar, improving blood pressure and most of all, weight reduction. It is the It is injected once weekly in the stomach, thigh or upper arm.

Tirzepatide acts as both a GLP-1 and a GIP receptor agonist, mimicking hormones that naturally secrete from the digestive tract after a meal. These hormones trigger insulin secretion, slow stomach emptying and signal to the brain that you’re full. Tirzepatide also works to regulate fat cells and suppress appetite.

As with any weight loss or wellness tool, Tirzepatide works best when combined with lifestyle changes.  It can help reduce appetite and suppress cravings, which really helps individuals maintain a healthy calorie deficit.  Many users report less “food noise,” meaning they find themselves thinking less and less about food.  Additionally, it can help boost metabolism, which allows the body to burn more calories at rest.

Benefits of Tirzepatide:

  • Promotes Weight Loss
  • Regulates Blood Sugar
  • Cardiovascular Benefits
  • Better Metabolic Health
  • Appetite Suppressant
  • Reduces Cravings
  • Amplifies Effects of Lifestyle Changes

How do you use Tirzepatide?

Tirzepatide is administered as a weekly subcutaneous injection into the abdomen, thigh or arm. It’s typically titrated, meaning that you start with a low dose and increase it at four-week intervals. Many individuals stay on the lower dose until weight loss stops or stalls, and then titrate up. Tirzepatide dosages are 2.5mg, 5mg, 10mg, 12.5mg and 15mg.

Research on Tirzepatide

One study of the Tirzepatide peptide was the GO-ITTib study, a phase 3 clinical trial that included a 36-week open-label Tirzepatide lead-in period and a 26-week double-blind placebo-controlled treatment period. Primary objective measures were changes in fasting visual analog scale (VAS) ratings of hunger, satiety, and fullness and prospective food intake at baseline and weeks 8, 16, and 28. Energy intake was measured during a buffet-style, ad libitum lunch. Results showed a statistically significant reduction in overall energy intake (food ingested) with both Tirzepatide and Semaglutide compared to placebo.

In the SURPASS 1-4 clinical trials, randomized participants treated with Tirzepatide experienced an average weight loss of 20.9 percent over 36 weeks. This weight loss was not the only benefit – there was also marked improvements in glycemic metrics, blood pressure and lipids.

In a new study, published in the journal Hypertension, researchers found that Tirzepatide significantly lowers blood pressure in people with diabetes and obesity.  Using ambulatory blood pressure monitoring (ABPM), which measures blood pressure every 30 minutes during the day and 60 minutes at night over a 24- to 27-hour period, participants in the study who were randomized to Tirzepatide or placebo showed that their systolic blood pressure (the top number in a BP reading) decreased more than with the placebo.

These results are the latest evidence that GLP-1 receptor agonists, like Tirzepatide  can improve cardiometabolic conditions that are often associated with diabetes and obesity. At 36 weeks, each Tirzepatide dose significantly lowered systolic BP and diastolic BP compared with placebo.

SUMMARY

Tirzepatide is a synthetic peptide that acts as both a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. As a result, it reduces appetite and slows down digestion, helping people feel full after eating, leading to weight loss. It also lowers blood sugar levels and improves glycemic control in people with diabetes.

Because of the way this peptide works, some things to watch out for are diarrhea or constipation, nausea and vomiting, heatburn, stomach pain, burping, or gas.  Most people report these side effects as being mild, and normally go away after their body adjusts to the peptide.

A significant percentage of people taking 10 mg or 15 mg of Tirzepatide achieved at least a 35% body weight reduction compared to 5% in the placebo group. Similar dose-response patterns were seen with improvements in systolic blood pressure and other prespecified cardiometabolic measures.

Insurance coverage for Mounjaro or Zepbound varies significantly among insurance plans.  Many will not cover either one, or have very high co-pays.  You can check your insurance plan’s formulary to see if they are covered.   If insurance is not an option, peptides through compounding pharmacies with a valid prescription.  Lastly, online peptide suppliers are available for research and development purposes.  If you are looking to conduct your own research, find a vendor that you trust.  Products should be independently tested for purity and strength.

The best play to buy peptides online – Pepolution of course!  Your best source for research peptides online.  If you are interested in connecting with other individuals conducting their own research, or have questions,  join the private group on FACEBOOK HERE.

 

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What Are Peptides?

What are peptides?

Peptides are a “hot” topic in today’s world. From GLP’s to Growth Hormones, peptides are gaining in popularity every day. A peptide is a string of amino acids that forms the building blocks of proteins. Peptides are a natural component of the body and perform many vital functions. They have been used in medicines for years and are not a new thing despite what many may think.

Peptides can be found in dietary supplements, medications, and skincare products. Some peptides must be injected, while others are taken orally. They have been linked to weight loss, muscle growth and many other health benefits.

Peptides are naturally made in the body and can be found in foods like eggs, milk, and fish. They can act as hormones, neurotransmitters, and growth factors. They are important for the body to function correctly. They can additionally be synthetic and be manufactured in a laboratory. They are designed to mimic the structure and function of a natural peptide. Scientists have interest in peptides that positively impact human health and have beneficial effects on the body.

Research indicates that peptides may:

  • Lower high blood pressure
  • Slow the aging process
  • Improve immune function
  • Act as an antioxidant
  • Improve wound healing
  • Prevent bone loss
  • Build strength and muscle mass
  • Reduce inflammation
  • Improve sleep quality
  • Increase libido

Weight Loss

One of the main reasons peptides have become so popular is their use in weight loss. They have been shown to be very effective in this area. Peptides that work for weight loss will often slow the movement of food through the digestive system and reduce cravings. There are usually minimal side effects that can include nausea, cramping, constipation, and diarrhea. Theses side effects often resolve with time.

Peptide weight loss therapy consists of a couple different phases. The loading phase is used to get your body accustomed to the peptide and is then transitioned to the weight loss phase. Once the target goal has been attained, the subject transitions to the maintenance phase. This phase involves smaller doses of the peptide to maintain the ideal body weight.

Everyone is different and each subject can have varied results. Weight loss can happen quickly or take several weeks. A balanced diet and regular exercise can aid in weight loss.

Skin Care

Adding peptides to your skincare routine can give you incredible anti-aging results, as well as smooth, plump skin. They work as tiny messengers to boost collagen production, improve elasticity and firmness and reduce fine lines and wrinkles. Some even contain antioxidant properties that help to protect your skin from free radicals, which can cause aging and discoloration.

Peptides also stimulate the cells to produce hyaluronic acid and other proteins that can plump and moisturize the skin for a smooth, radiant complexion. They can also reduce inflammation, which is great for those with sensitive skin and breakouts.

Look for peptide-rich products in serums, boosters or moisturizers and avoid using them with cleansers, as they might not penetrate the skin. Also, be patient with peptides as they take time to work. You may need to use them consistently for weeks or even months before seeing the best results. Be sure to use them in conjunction with other skin-boosting ingredients like retinol and hyaluronic acid for even better results.

Immune System

Peptides are short chains of amino acids that can stimulate the immune system and fight off diseases like cancer. They also play a role in many other biological functions, including blood pressure regulation, anti-microbial properties, and improved response to infection.

Peptide immunotherapy uses peptide-based vaccines to trigger the body’s natural antibodies to target specific tumor cells. Peptide vaccines can be designed to target B- or T-cell epitopes, allowing the body to develop high-affinity antibodies that will kill the cancer cells.

A peptide designed to modulate the CD2-CD58/CD48 interaction was found to significantly inhibit macrophage activation and inflammatory cell adhesion in rheumatoid arthritis (RA). The peptide was shown to be effective by blocking CD8 T-cell costimulation, which is necessary for T-cell reprogramming and immune suppression in RA. These findings indicate the potential for peptides to serve as anti-inflammatory, pro-resolving chemotherapeutic agents in RA. The study was published in the journal Science Immunology.

Where to buy peptides?

Peptides can be purchased through pharmacies, wellness clinics and many online stores. Make sure you do your research and find a reputable source.

Don’t know where to start? Take a look at Pepolution for all your research peptide needs! Pepolution’s products are not dietary supplements or medications. It is your responsibility to use them in a legal manner.